home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410p.zip
/
M94A3335.TXT
< prev
Wrap
Text File
|
1994-10-25
|
2KB
|
40 lines
Document 3335
DOCN M94A3335
TI Differences in immune function among patients infected with distinct
Thailand HIV-1 strains.
DT 9412
AU Weniger BG; Tansuphaswadikul S; Young NL; Pau CP; Lohsomboon P;
Yindeeyoungyeon W; Limpakarnjanarat K; Division of HIV/AIDS (E-50), CDC,
Atlanta, Georgia 30333.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):10 (abstract no. 012C). Unique
Identifier : AIDSLINE ICA10/94369240
AB INTRODUCTION: Thai HIV-1 genotype A/subtype E and genotype B/subtype B
circulate widely in Thailand, with A spread most often by sex and B
predominant among IDUs. METHODS: Among symptomatic HIV+ Bangkok
outpatients (n = 60) and inpatients (n = 267) from 8/91-9/92, 216 A and
73 B infections were serotyped and compared. RESULTS: Of 162 sexual
risk-group patients, 99% (160) had genotype A, while 86% (66) of 77 IDUs
had B. Type As had lower mean CD4+ levels (204/microL, 11.4%) than Bs
(310/microL, 20.0%, p < .001). CD4+ cells < 200/microL or < 14% occurred
in 64% (133/209) of As and 44% (31/71) of Bs (p = .003). All 17
Pneumocystis diagnoses were in As (p < .01), as were all 34 non-Candida
mycoses (p < .001). However, TB occurred less often in As (33%) than Bs
(53%, p = .002). Inpatient mortality rate was 20% among As and 12% among
Bs (p = .14). Regression and classification tree analyses among men
21-49 (to avoid sex and age confounding) found A independently
associated with lower CD4+ levels, and not confounded by risk group. The
differing opportunistic conditions, however, appeared to be mediated by
the CD4+ levels. CONCLUSION: Different pathophysiologic manifestations
of viral phenotype in patients with distinct HIV-1 strains may
contribute to the segregation of strain by risk group.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/MICROBIOLOGY/
TRANSMISSION Adult AIDS-Related Opportunistic Infections/DIAGNOSIS
Female Genotype Human HIV-1/GENETICS/*IMMUNOLOGY Male Middle Age
Serotyping Sexually Transmitted Diseases/MICROBIOLOGY Substance Abuse,
Intravenous/COMPLICATIONS Thailand/EPIDEMIOLOGY T4 Lymphocytes
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).